Tough question to answer in a broad sense. I think it completely depends on your game and swing. It seems higher handicaps tend to be able to make more consistent contact with a hybrid.
Personally, I find a hybrid to suit my game better than a 2 iron. I feel comfortable with both, but am more consistent with hybrid (Callaway XR Pro 3H). Safe tee shots, fairway into par 5s, short par 4s is typically where I use that club. For me, a 2 iron is better out of the rough, but I rarely need that type of length from poor lies anyway.
Anyways, it’s very subjective depending on the player.